The influence of drug-like concepts on decision-making in medicinal chemistry

-
The application of guidelines linked to the concept of drug-likeness, such as the 'rule of five', has gained wide acceptance as an approach to reduce attrition in drug discovery and development. However, despite this acceptance, analysis of recent trends reveals that the physical properties of molecules that are currently being synthesized in leading drug discovery companies differ significantly from those of recently discovered oral drugs and compounds in clinical development. The consequences of the marked increase in lipophilicity — the most important drug-like physical property — include a greater likelihood of lack of selectivity and attrition in drug development. Tackling the threat of compound-related toxicological attrition needs to move to the mainstream of medicinal chemistry decision-making.

Link to article

Comments

Post a Comment

Popular posts from this blog

Databases on the FDA Website

-
The search engine on the FDA Website will not find information that is in the databases that make up a large part of the site. Those databases can be accessed separately, using the links below. Following each link is a brief description of the database. Animal Feed and Drugs FDA Approved Animal Drug Products : A listing of searchable databases in the following categories: Approved Animal Drug Products (Basic search), Approved Animal Drug Products (Advanced search), Suitability Petitions, Sponsors, Green Book, Code of Federal Regulations, Federal Register, Patents, and Exclusivity. FDA BSE/Ruminant Feed Inspections Firms Inventory : Inspection information of renderers, feed mills, ruminant feeders, protein blenders, pet food manufacturers, pet food salvagers, animal feed distributors and transporters, ruminant feeders, and others regarding compliance with the BSE/Ruminant Feed regulations. Biological Products Adverse Event Reporting System : The Adverse Event Reporting System is a compu...
Read more

IPEXL - New Patent Search Tool

-
Image
IPEXL has released the beta version for their Patent Search tool. Its really nice and provides many feature. Must to have a look for patent professionals. Features: Patent Search - Patent search over China, Taiwan, Hong Kong, Singapore, Japan, S. Korea, PCT, United States, Europe, UK and Canada with translation link through google translator. Patent Directory - Patent search based on IPC class IP Market Place - Patents open for license.
Read more

Employee Retention – A critical issue, why..and How to solve?

-
Developing an employee retention plan is important to prevent raiding of your staff. This tool includes ideas on keeping employees happy, the business connection, time and money, and more. Using these tools and techniques, you can make better decisions on how to retain your top employees. Key employee retention is critical to the long term health and success of your business . Employee retention matters. Organizational issues such as training time and investment; lost knowledge; mourning, insecure coworkers and a costly candidate search aside, failing to retain a key employee is costly. Various estimates suggest that losing a middle manager costs an organization up to 100 percent of his salary. The loss of a senior executive is even more costly. Employee retention is one of the primary measures of the health of your organization. If you are losing critical staff members, you can safely bet that other people in their departments are looking as well. It is important for the management t...
Read more