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PatIndia is started to collect, generate and represent most of the patent related information in a single platform, so that it can help Patent Analysts in their searches, analysis and prediction of competitive and technological intelligence information from patents and other informational resources.

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All pharmaceutical companies have to operate in accordance with FDA regulations. Recently the FDA has issued guidelines that determine quality control standards for the pharmaceutical production process. For these companies this implies that they will have to measure every important parameter within their production process in order to control and optimize it. Oracle technology in combination with KMX provided a valuable insight in the production process. By applying data mining, generating all possible models from the data and analyzing all relationships between the models. Further optimization of the thus generated models provided not only better quality control of the production process, as required by the FDA, but also greatly improved production planning and saved production costs.
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The application of guidelines linked to the concept of drug-likeness, such as the 'rule of five', has gained wide acceptance as an approach to reduce attrition in drug discovery and development. However, despite this acceptance, analysis of recent trends reveals that the physical properties of molecules that are currently being synthesized in leading drug discovery companies differ significantly from those of recently discovered oral drugs and compounds in clinical development. The consequences of the marked increase in lipophilicity — the most important drug-like physical property — include a greater likelihood of lack of selectivity and attrition in drug development. Tackling the threat of compound-related toxicological attrition needs to move to the mainstream of medicinal chemistry decision-making. Link to article
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